Health and Wellbeing

Contact: Lina Sarro

The health and wellbeing theme addresses the challenges related to the design and implementation of miniaturized biomedical systems for Precision Medicine, Personalized Care, and Healthy Lifestyle. It spans from material research and technology development, through device and circuit design, to signal processing and system implementation. It covers both in-vivo and in-vitro devices and systems as well as advanced imaging and diagnostic instrumentation.

Technological challenges are miniaturization, accuracy and reliability, energy efficiency, biocompatibility, manufacturability and costs. The aim is to contribute to faster and more accurate diagnostics, to advanced therapy, to an improved quality of life (also for healthy people to improve productivity and overall societal participation), and more in general for a better care, more efficient and less costly. Examples of programs within the teams are the hDMT initiative (organ-on-a-chip platform); intelligent catheters for intervention; steering deep brain stimulation probes.

The groups in the EEMCS involved in the Health and Wellbeing theme are well-positioned to address the abovementioned challenges as there is already a significant activity in this area, good interaction with other research groups, both nationally and internationally, and the expertise required in material science, technology development, circuit design and system integration is present.

This theme covers biomedical technology, from sensors and materials to electronics, signal processing, and systems.
Some specific directions are:

  • "In vitro": e.g. organs-on-chip
  • "In vivo": e.g. bioelectronics for low power wireless technology and implantable stimulators, such as cochlear implants and neural stimulators for treatment of tinnitus.
  • biomedical signal processing and imaging, e.g. ultrasound sensor arrays, high-tesla MRI, audio signal processing, in particular for improved understanding with hearing aids.

Projects under this theme

ReaSONS 2 Demo: Realtime Sensing of Neural Signals Demonstrator

Demonstrator of recording tiny neural signals on top of the stimulus and artifact. NWO Demonstrator Grant.

ATiNaRI: Asynchronous Time-domain Neural Recording Interfaces

Intelligent Catheters in Advanced Systems for Interventions (INCITE) – WP2 Imaging

Earlier recognition of cardiovascular diseases

Atrial Fibrillation FIngerPrinting: Spotting Bio-Electrical Markers to Early Recognize Atrial Fibrillation by the Use of a Bottom-Up Approach

AFFIP -- Atrial Fibrillation FIngerPrinting: Spotting Bio-Electrical Markers to Early Recognize Atrial Fibrillation by the Use o

STW and DHF project (14728). Program leader: Dr. N.M.S. de Groot (ErasmusMC), workpackage leader WP4, High Density Mapping Array: prof.dr.ir. W.A. Serdijn

Computational neuroscience and bio-inspired circuits and algorithms

Low-power neuro-inspired or neuromorphic circuits and algorithms; low-power circuits and systems for neural interfacing.

Good Vibrations - Fast and Robust Wave Field Computations in Complex Structures Using Krylov Resonance Expansions

Using Krylov subspace reduction techniques to solve wave field problems in complex media (resonanting nano-scale devices and seismic exploration)

Integrated Circuits for Intra-Vascular Ultrasound Imaging

In this project, we develop integrated circuits to enable the next generation of 3D intra-vascular ultrasound probes

InForMed

An Integrated Pilot Line for Micro-Fabricated Medical Devices

InForMed: D4 - Steering deep brain stimulation probe (Chip-in-Tip)

Dielectric enhanced MRI

Modeling and analyzing the effect of high permittivity pads in MRI imaging

Spatially Correct Multi-Microphone Noise Reduction Strategies suitable for Hearing Aids

multichannel signal processing algorithms to help hearing aid users

Integrated Near Field sensOrs for high Resolution MicrowavE spectRoscopy

The goal of this project is the creation of a new class of sensors, enabling fast and accurate dielectric characterization of biological samples, with high-sensitivity and high-spatial resolution.

Sensing Devices for Organ on Chip Technology

3D Plane-wave ultrasound matrix transducer for carotid artery diagnosis

In this project, we will develop a very powerful, three-dimensional (3D) ultrasound system for real-time imaging of the carotid arteries.

BiopsyPen: A portable coherent tomography scanner

Three-Dimensional CMOS Photon Counting for Medical Imaging and Cancer Diagnostics

SPAD technology for TOF-PET applications

Ultra-fast GSDIM super resolution microscopy using a SPAD-array camera

Visualization of nanoscopic cellular structures using nonswitchable standard fluorophores

MASSIVE - Autonomous Vital Sign Monitoring

In this research program, we work on electroceuticals that wirelessly receive power and wirelessly transmit vital signs like body temperature, ECG, EMG, EEG and ECoG.

Miniature ultrasound probes for real-time 3D imaging and monitoring of cardiac interventions

This research project will enable the next generation of miniature ultrasound probes for real-time 3D transesophageal echocardiography, suitable for use in small children and newborns.

REASONS – Realtime Sensing of Neural Signals

This project targets the development of a completely new readout system for measuring the so called electrically evoked compound action potential (eCAP) coming from the auditory nerve.

Intelligibility enhancement for speech communication systems

Can we do "precoding" of speech signals to enhance their intelligibility at the receiver, taking channel distortions and environmental noise into account?

Sensors and Circuits on Catheters

How to bring highly miniaturized circuits, sensors and actuators to the tip of the catheters and other minimal invasive surgical instruments?

SINs - Smart Implantable Neurostimulators

In this research program we push the research and development of technology for research on and treatment of a multitude of brain disorders, a.o., tinnitus and addiction.

Smart Flexible Sensors for in-vivo Coronary Circulation Diagnostics

Combined pressure and flow sensor, so small that it can be positioned in the tip of the guide wire used in heart angioplasty surgery

Living Chip: Stretchable Multi-Electrode Array for drug screening with stem-cell-derived cardiomyocytes

Stem cell derived human cardiomyocytes are used to detect cardiotoxic side effects of newly developed drugs

History

Heterogeneous Inception

Developing and deploying a unified design methodology and tools for system-level design and verification of heterogeneous systems

Non-Invasive High Resolution Near-Infrared Imaging for Hemodynamics Monitoring and Tumor Detection

Large high-resolution imaging sensor aimed at the diagnosis and treatment of cancer and functional imaging of the brain

Novel multimodal endoscopic probes for simultaneous PET/ultrasound imaging for image-guided interventions

Development of new, higher performance imaging techniques with multimodal capability for endoscopic procedures in diagnostic and therapeutic endoscopy and in surgical oncology.

Fully Networked, Digital Components for Photon-starved Biomedical Imaging Systems

Array of single-photon detectors arranged in a network of tens of dies for application in PET imaging

Intelligibility Enhancement of Noisy Speech

The objective of the project is to develop a speech enhancement system which specifically aims at improving the intelligibility of the speech signal.