Department of Microelectronics
Faculty of Electrical Engineering, Mathematics, and Computer Science

dr. P.A. Motreuil-Ragot

PhD student
Electronic Components, Technology and Materials (ECTM), Department of Microelectronics

PhD thesis (Jul 2023): Ionic electroactive polymer for organs-on-chip applications
Promotor: Lina Sarro, Massimo Mastrangeli

Themes: Health and Wellbeing

Biography

My research interest is focused on microfabrication and material science for Organs-on-chip (OoCs). My doctoral work concerns the development of a smart material-based OoC platform that could allow actuation and sensing of tissue activity using the same culture substrate, as well as on-chip microfluidic pumping.

I got my master's degree in Biomedical Engineering from Université de Strasbourg, France. During my studies, I had the opportunity to do several internships in both public and private institutes. In particular, I had a 4-month experience in TissUse Gmbh (Berlin, Germany) where I developed a computer vision software for automation of measurements in OoCs. I did my master thesis in the French Alternative Energies and Atomic Energy Commission (CEA, Grenoble), where I could develop a 3D skin-on-chip model using hydrogel and Micronit’s OoC platform. During my past experiences I could learn a lot about tissue engineering, microfluidic and innovation.
Now I have the privilege to collaborate with multi-disciplinary teams within the Netherlands Organ-on-Chip Initiative (NOCI) and to perform collaborations to manufacture innovative silicon/polymer-based OoC devices.

Publications

  1. Standardizing designed and emergent quantitative features in microphysiological systems
    D. Nahon; R. Moerkens; H. Aydogmus; B. Lendemeijer; A. Martínez-Silgado; J. Stein; M. Dostanic; J.-P. Frimat; C. Gontan; M. de Graaf; M. Hu; D. Kasi; L. Koch; K. Le; S. Lim; H. Middelkamp; J. Mooiweer; P. Motreuil-Ragot; E. Niggl; C. Pleguezuelos; J. Puschhof; N. Revyn; J. Rivera; J. Slager; L. Windt; M. Zakharova; B. van Meer; V. Orlova; F. de Vrij; S. Withoff; M. Mastrangeli; A. van der Meer; C. L. Mummery;
    Nature Biomedical Engineering,
    Volume 8, pp. 941-962, 2024. DOI: 10.1038/s41551-024-01236-0

  2. Manufacturing thin ionic polymer metal composite for sensing at the microscale
    Paul Motreuil-Ragot; Andres Hunt; Leandro N. Sacco; Pasqualina M. Sarro; Massimo Mastrangeli;
    Smart Materials and Structures,
    Volume 32, pp. 035006, 2023. DOI: 10.1088/1361-665X/acb305

  3. Ionic electroactive polymer for organs-on-chip applications
    Paul Motreuil-Ragot;
    PhD thesis, Delft University Technology, 2023. DOI: 10.4233/uuid:5f72b863-c05f-4bfb-82e6-b75dc63923cd

  4. Rapid Prototyping of Organ-on-a-Chip Devices Using Maskless Photolithography
    Dhanesh G. Kasi; Mees N. S. de Graaf; Paul A. Motreuil-Ragot; Jean-Phillipe M. S. Frimat; Michel D. Ferrari; Pasqualina M. Sarro; Massimo Mastrangeli; Arn M. J. M. van den Maagdenberg; Christine L. Mummery; Valeria V. Orlova;
    Micromachines,
    Volume 13, pp. 49, 2022. DOI: 10.3390/mi13010049

  5. Ionic polymer metal composite-based microfluidic flow sensor for bio-MEMS applications
    P. Motreuil-Ragot; G. Turcan; B. de Wagenaar; A. Hunt; P. M. Sarro; M. Mastrangeli;
    In IEEE SENSORS 2022,
    30 October - 2 November 2022. DOI: 10.1109/SENSORS52175.2022.9967281

  6. Analysis of Platinum Distribution within a Nafion 212 Membrane during Electroless Deposition
    P. Motreuil-Ragot; A. Hunt; L. N. Sacco; P. M. Sarro; M. Mastrangeli;
    In 242nd Electro Chemical Society Meeting,
    9-13 October 2022.

  7. Ionic polymer metal composite (IPMC)-based micropump for organs-on-chip
    P. Motreuil-Ragot; D. Kasi; B. de Wagenaar; A. Hunt; V. Orlova; A. M. J. M. van den Maagdenberg; P. M. SARRO; M. Mastrangeli;
    In EUROoCS Conference 2022,
    4-5 July 2022.

  8. Microelectronmechanical organs-on-chip
    Massimo Mastrangeli; Hande Aydogmus; Milica Dostanic; Paul Motreuil-Ragot; Nele Revyn; Bjorn de Wagenaar; Ronald Dekker; Pasqualina M. Sarro;
    In 21st Int. Conf. on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS 2021),
    online, 20-25 June, 2021.

  9. Enabling Actuation and Sensing in Organs-On-Chip Using Electroactive Polymers
    P. Motreuil-Ragot; A. Hunt; D. Kasi; B. Brajon; A. M. J. M. van den Maagdenberg; V. Orlova; M. Mastrangeli; P. M. Sarro;
    In IEEE 3rd International Conference on Soft Robotics (RoboSoft 2020),
    2020. DOI: 10.1109/RoboSoft48309.2020.9115977

  10. Enabling actuation and sensing in organs-on-chip using electroactive polymers
    P. Motreuil-Ragot; A. Hunt; D. Kasi; B. Brajon; A. van den Maagdenberg; V. Orlova; M. Mastrangeli; P. M. Sarro;
    In International MicroNanoConference,
    Utrecht (NL), December 10-11, 2019.

  11. Microengineered organs-on-chip
    H. Aydogmus; M. Dostanic; P. Motreuil-Ragot; M. Mastrangeli; P. M. Sarro;
    Poster, presented at QBio Symposium, Utrecht (NL), October 29, 2019.

BibTeX support

Last updated: 6 Jul 2023

Paul Motreuil-Ragot

Alumnus
  • Left in 2022
  • Now: CEA (Grenoble, FR)

MSc students