Konstantina Kolovou-Kouri

Publications

  1. Development of dorsal root ganglion (DRG) multichannel stimulator prototype for use in early clinical trials
    K. Kolovou-Kouri; S. Soloukey; B.S. Harhangi; W.A. Serdijn; V. Giagka;
    In Book of Abstracts, 8th Dutch Biomedical Engineering Conf. (BME) 2021,
    Virtual, 28-29 January 2021.
    document

  2. Dorsal Root Ganglion (DRG) Versatile Stimulator Prototype Developed for Use in Locomotion Recovery Early Clinical Trials
    Konstantina Kolovou-Kouri; Sadaf Soloukey; Frank Huygen en Sanjay Biswadjiet Harhangi; Wouter Serdijn; Vasiliki Giagka;
    In Proc. 2021 10th International IEEE/EMBS Conference on Neural Engineering (NER),
    Online, IEEE, May 4-6 2021.
    Keywords: ... Neural Interfaces - Neural stimulation, Motor Neuroprostheses - Neuromuscular stimulation, Neuromuscular Systems - Locomotion, posture and balance.

    Abstract: ... This paper presents the development of a Dorsal Root Ganglion (DRG) stimulator system intended for use in early clinical trials for motor recovery after Spinal Cord Injury (SCI). It allows for independent control of multisite/multilevel bilateral (on both sides of the spinal cord) stimulation, it can supply a high output current of 25.4mA, and has the ability to program pulse sequences similar to actual locomotion patterns. These characteristics ultimately provide the required versatility for examining the effects of DRG stimulation on locomotion recovery, which is lacking in currently available commercial systems. The device is created using commercially available components to make the design reproducible by other research labs and to facilitate the critical approval procedure for use in a clinical research environment. Throughout the design phase, essential considerations regarding the safety of the participating patient, as well as of the medical personnel involved, were taken into account and these are analyzed and demonstrated in this paper. Such considerations are very rarely discussed in scientific literature and the authors consider that, apart from the design of the system itself, this discussion is a critical contribution of this paper.

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