BSc thesis project proposal
[2016] Transcranial Magnetic Stimulation in Mice [Already taken]
Project outside the university
Erasmus Medical Center, Department of Neuroscience, RotterdamIn humans, the brain can be stimulated non-invasively with transcranial magnetic stimulation (TMS). This technique uses specific coils, which can create an electric field in the brain large enough to excite neurons (brain cells). The applications of this technique are numerous, ranging from fundamental scientific to clinical purposes. However, the exact mechanisms by which one can excite neurons and even induce neuronal plasticity are still unknown, as in humans one cannot measure neuronal activity by means of invasive extra-cellular recordings during TMS. Therefore, we want to develop a coil suitable for exiting neurons in the mouse brain to investigate the exact mechanisms underlying TMS. We are convinced that a deeper understanding of these mechanisms leads to better and more reliable application of this beautiful brain stimulation technique.
Assignment
To develop a stimulation coil, necessary electronics and software interfaces, allowing excitation of neurons in the mice brain non-invasively.Requirements
Program, Demands, Location:Students will develop concepts of stimulation coils, suited for exciting neurons in the mouse brain in vivo. Electric field maps should be modelled regarding the permeability of the mouse brain. This should be done together with designing the electric circuitry needed for performing magnetic stimulation. One or more coils and circuitries will then be developed, and evaluated in an experimental setup. The modelling activities will mainly take place at the TU Delft, whereas the practical ones will take place at the Erasmus MC (Rotterdam) preferentially. Dates at which the students will visit Rotterdam should be discussed with Myrthe Ottenhoff (contact info below).
Contact
prof.dr.ir. Wouter Serdijn
Bioelectronics Group
Department of Microelectronics
Last modified: 2021-05-26
