Agenda

MSc ME Thesis Presentation

In-vivo multicell inferior olivary recordings: alternative design methods for creating cheap and flexible electrode structures

Joost Kerpels

In order to allow neuroscientists to do in-vivo recordings on hard to reach brain tissue, such as the Inferior Olivary Complex, specially designed electrodes are required. Although a variety of electrodes are commercially available, they are usually expensive and it is hard to rapid prototype new designs.

This thesis describes the design process of three electrode array designs, each improved based on the findings of the previous one. The first design was made using a FlexPCB production technique, on which gold spots were added to create conducting measuring sites. The second design combined this technique with commercial microwire electrodes. The third design used 3d-print technology combined with microwire electrodes to create an electrode array.

All designs were tested in in vivo measurements on mice. Although successful measurements were done, the robustness and reproducibility needs to improve in order for this technique to really be applicable in a laboratory environment. Furthermore, the peripherals need to be improved in order to minimize the system to create a wearable system and perform recordings on wake animals.

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Overview of MSc ME Thesis Presentation